Crystallographic studies of DNA minor groove binding drugs
نویسندگان
چکیده
منابع مشابه
Antineoplastic DNA-binding compounds: intercalating and minor groove binding drugs.
DNA intercalating and minor groove binding compounds are new weapons in the battle against malignant diseases. These antineoplastic agents target the DNA molecule and interfere with the cell cycle leading to rapidly proliferating cell death. They are mainly derivates of a naturally occurring organic compound derived from a microorganism or plant. Intercalators usually act as topoisomerase I and...
متن کاملTargeting DNA-binding drugs to sequence-specific transcription factor.DNA complexes. Differential effects of intercalating and minor groove binding drugs.
Intercalating, minor groove binding, and covalently bonding drugs were evaluated by mobility shift assays for their ability to interfere with transcription factors binding to their respective DNA recognition sequences. The Cys2His2 zinc finger proteins EGR1, WT1, and NIL2A, the basic leucine-zipper protein wbJun/wbFos, and the minor groove binding protein hTBP were chosen as representative tran...
متن کاملPotent inhibition of werner and bloom helicases by DNA minor groove binding drugs.
Maintenance of genomic integrity is vital to all organisms. A number of human genetic disorders, including Werner Syndrome, Bloom Syndrome and Rothmund-Thomson Syndrome, exhibit genomic instability with some phenotypic characteristics of premature aging and cancer predisposition. Presumably the aberrant cellular and clinical phenotypes in these disorders arise from defects in important DNA meta...
متن کاملTheoretical Studies on the Binding of SN6999 to the Minor Groove of DNA
SN6999 is a drug with antitumor activity (Denny, 1979). It binds to the minor groove of B-DNA, preferentially at pure AT stretches. The binding of SN6999 to the DNA dodecamer d(GGTTAATGCGGT) d(ACCGCATTAACC) was recently studied by NMR spectroscopy (Chen, 1992). It was found that SN6999 is likely to bind in two orientations relative to the DNA, but no models at atomic resolution were derived. Sl...
متن کاملMinor groove-binding architectural proteins: structure, function, and DNA recognition.
To date, high-resolution structures have been solved for five different architectural proteins complexed to their DNA target sites. These include TATA-box-binding protein, integration host factor (IHF), high mobility group I(Y)[HMG I(Y)], and the HMG-box-containing proteins SRY and LEF-1. Each of these proteins interacts with DNA exclusively through minor groove contacts and alters DNA conforma...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2011
ISSN: 0108-7673
DOI: 10.1107/s0108767311092853